Nox4 Polyclonal Antibody for Rat(Rattus norvegicus) | EIAab.comNox4 Polyclonal Antibody for Rat(Rattus norvegicus)

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Index > Protein center > Nox4(Gene name) > Rat

Nox4 (Gene name),

NADPH oxidase 4 (Protein name ), NOX4_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Nox4(Kox);

Protein name:

NADPH oxidase 4;

Alternative:

Kidney superoxide-producing NADPH oxidase;Kidney oxidase-1(KOX-1);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with TLR4 (By similarity). Interacts with, relocalizes and stabilizes CYBA/p22phox. Interacts with protein disulfide isomerase.

Function:

Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell junction focal adhesion May localize to plasma membrane and focal adhesions.

Protein Attributes:

Sequence length:

578

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

578:

SISKTLHNLS | NRNNSYGTKF | EYNKESFS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.14744

String:

Q924V1

KEGG:

rno:85431

STRING:

10116.ENSRNOP00000018868

Pfam:

PF08022

Uniprot:

Q924V1

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ELISA Kit for Rat NADPH oxidase 4

Cat.:

E1488h

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96T

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ELISA Kit for Rat NADPH oxidase 4

Cat.:

E1488r

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96T

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ELISA Kit for Rat NADPH oxidase 4

Cat.:

E1488m

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Looking for manual.

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96T

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CLIA Kit for Rat NADPH oxidase 4

Cat.:

U1488h

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Packing:

96T

CLIA Kit for Rat NADPH oxidase 4

Cat.:

U1488m

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MSDS:

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Packing:

96T

CLIA Kit for Rat NADPH oxidase 4

Cat.:

U1488r

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Packing:

96T

Polyclonal Antibody for Rat NADPH oxidase 4

Cat.:

P1488Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat NADPH oxidase 4

Cat.:

P1488Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat NADPH oxidase 4

Cat.:

P1488Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat NADPH oxidase 4

Protein for Rat NADPH oxidase 4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Novel gp91(phox) homologues in vascular smooth muscle cells: nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways."
Lassegue B. , Sorescu D. , Szoecs K. , Yin Q. , Akers M. , Zhang Y. , Grant S.L. , Lambeth J.D. , Griendling K.K.
Circ. Res.88:888-894(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain: Sprague-Dawley.
tissue: Vascular smooth muscle.
2.

"A novel superoxide-producing NAD(P)H oxidase in kidney."
Shiose A. , Kuroda J. , Tsuruya K. , Hirai M. , Hirakata H. , Naito S. , Hattori M. , Sakaki Y. , Sumimoto H.
J. Biol. Chem.276:1417-1423(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells."
Hilenski L.L. , Clempus R.E. , Quinn M.T. , Lambeth J.D. , Griendling K.K.
Arterioscler. Thromb. Vasc. Biol.24:677-683(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
4.

"Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase."
Ambasta R.K. , Kumar P. , Griendling K.K. , Schmidt H.H.H.W. , Busse R. , Brandes R.P.
J. Biol. Chem.279:45935-45941(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CYBA;SUBCELLULAR LOCATION;MUTAGENESIS OF HIS-119
5.

"Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney."
Gorin Y. , Block K. , Hernandez J. , Bhandari B. , Wagner B. , Barnes J.L. , Abboud H.E.
J. Biol. Chem.280:39616-39626(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
6.

"Regulation of NAD(P)H oxidase by associated protein disulfide isomerase in vascular smooth muscle cells."
Janiszewski M. , Lopes L.R. , Carmo A.O. , Pedro M.A. , Brandes R.P. , Santos C.X.C. , Laurindo F.R.M.
J. Biol. Chem.280:40813-40819(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PROTEIN DISULFIDE ISOMERASE;SUBCELLULAR LOCATION

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